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In essence, a granulator is a multipurpose processor that’s equally suitable for the high-speed dispersion of dry powders, aqueous or solvent granulations, effervescent products, wet and melt pelletization. This method eliminates instability problems during processing due to water and also proven advantageous as the pellets produced by melt extrusion do not require additional film coating since the drug release is diffusion controlled. Multiple unit dosage forms (MUDFs), are formulated as granules, pellets, or mini tabletsThe most increasingly interesting area in the development of MUDF’S is incorporation into tablets instead of hard gelatin capsules in order to make it more economical to the consumers and gaining more attention currently.
Coalescence is defined as the formation of large-sized particles by random collision of well-formed nuclei, this mechanism require slightly excess moisture on the surface of the nuclei although the number of nuclei is progressively reduced even though the total mass of the system remains unchanged during this operation.
This drug delivery platform shows business potential promise for future in pharmaceuticals, nutraceuticalsThus Pellets have attracted more attention due to their unit clinical and technical advantages.Nucleation is a stage of Pelletization process that occurs whenever a powder is wetted with solvent system. Keywords: Fluid-bed Technology, Pelletization, Granulation, Formulation development, Agglomeration. Other cooling agents’ likeWS3, WS23 and Utracoll II can also be used in conjunction with flavors (The sweetness of fructose is dissolved rapidly in the saliva compared to sucrose and dextrose and also sweeter than sorbitol and mannitol for which it’s used widely as a sweetener. The interest in pellets as dosage forms (filled into hard gelatin capsules or compressed into disintegrating tablets) has been increasing continuously, since their multi-particulate nature offers many important pharmacological as well as technological advantages over conventional single-unit solid dosage forms. The temperature maintained in the spheronizer should be high enough to soften the extrudate partially and facilitate its deformation and eventual spheroid formation.Most of the coating processes use one of three general types of equipments.The mechanism of action of the binder involves formation of liquid bridge that holds the particles together; but as the liquid evaporates the precipitating and hardening of binder takes place leading to main bonding force and with a possibility of the soluble constituents to crystallize and contribute to the bonding mechanisms In the spray-drying process, the binder is intimately mixed as suspension or solution form with the drug to provide a fairly cohesive mixture which results in the pellets with appreciable strength after drying The binders are commonly used in the range of 2-10%w/w or v/v and should be optimized so that the pellets are durable and not friable and yet to maintain the other desirable properties of the pellets, such as releasing the drug at the intended rate.Different types of granulating fluid are used for the pelletization process. Fludised Bed Granulator Advantages It reduces product loss.
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In the rotary cylinder extruder, one of the two counter rotating cylinders is hollow and perforated, whereas the other cylinder is solid and acts as a pressure roller (In the rotary gear extruders there are two hollow counter rotating gear cylinders with counter board holes.
Fluid bed granulation process improves the dissolution efficiency of both nimodipine and spironolactone tablets.
Multiparticulate drug delivery systems
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